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Phospho-P38 (T180 + Y182) Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Synthetic phospho-peptide corresponding to residues surrounding Thr180 and Y182 of human P38.
Human, Mouse, Rat
WB
Predicted band size: 41 kDa
NIH/3T3 treated with 250ng/mL anisomycin for 30 minutes cell lysate, HeLa treated with 25μg/mL anisomycin for 30 minutes cell lysate, C6 treated with 25μg/mL anisomycin for 30 minutes cell lysate, PC-12 treated with UV for 1 hour cell lysate.
unconjugated
Liquid
1ug/ul
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
IgG
Immunogen affinity purified.
WB
1:500-1:2,000
| Mouse | 查看 17 篇文献如下 |
| Human | 查看 8 篇文献如下 |
| Rat | 查看 2 篇文献如下 |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets.
1. Deak M. et. al. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 17:4426-4441(1998).
Cytoplasm, Nucleus.
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